Abstract: Objective To investigate the relationship between non-alcoholic fatty liver disease and pulse wave velocity. Methods The clinical data of 208 subjects enrolled were analyzed retrospectively. Results The prevalence of NAFLD was 16.8% (35/208), and there was no significant difference in the prevalence
of NAFLD between male and female. Compared with normal group, NAFLD subjects were older and had significant higher body weight, waist circumference, BMI, systolic blood pressure, blood glucose, triglycerides, LDL, ALT and GGT. Compared to controls, the average BaPWV of NAFLD subjects both male
and female were significant higer. In multiple regression analysis, age, BMI, systolic blood pressure, blood glucose, LDL, GGT and NAFLD contributed to average BaPWV. Furthermore, in the NAFLD subjects, BMI, systolic blood pressure, blood glucose and LDL contributed to average BaPWV. There was positive correlation between BMI, systolic blood pressure, blood glucose, LDL and average BaPWV in NAFLD group. Conclusions Compared to controls, NAFLD subjects had more severe atherosclerosis, and PWV was a valuable indicator to assess the extent of atherosclerosis in NAFLD subjects.