Abstract: Objective To observe the treatment effect of Tanreqing combined with magnesium isoglycyrrhizinate on hospitalized children with acute jaundice hepatitis A. Methods The clinical data of 116 hospitalized children with acute jaundice hepatitis A in our hospital from August 2010 to April 2013 were
analyzed retrospectively. The control group (60 cases from August 2010 to December 2011) were treated with magnesium isoglycyrrhizinate injection combined with inosine injection and vitamin C injection for 2 weeks. The treatment group (56 cases from January 2012 to April 2013) were given Tanreqing injection combined with Magnesium isoglycyrrhizinate for 2 weeks. Changes of the main symptoms, signs, key indicators of liver function (ALT, ALB and TBil) in patients were observed before and after treatment, and the clinical effects were analyzed. Results Clinical symptoms improvement rate, liver function recovery rate and the duration of treatment group were superior to the control group, and the effective rate of treatment group was 89.28%（P = 0.002). Conclusions The effect of Tanreqing in children with acute jaundice hepatitis A was significantly better than that of conventional treatment.