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干扰素对慢性HBV感染者T淋巴细胞趋化因子受体及血清趋化因子表达水平的影响

作者：胡蓉康信通曾义岚刘勇罗东霞尚鹏程毛创杰邓杨

单位：成都市公共卫生临床医疗中心成都 610066

关键词：干扰素慢性HBV感染 T淋巴细胞趋化因子受体

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出版年,卷(期):页码：2015,7(4):42-46

摘要：

摘要：目的探讨抗病毒治疗对慢性HBV感染者T淋巴细胞趋化因子受体及血清趋化因子表达水平的影
响。方法选取成都市公共卫生临床医疗中心于2012年5月至2012年12月收治的肝炎患者100例，其中
男68例，女32例，年龄34～72岁，平均年龄为（54.6 ± 4.3）岁，分为慢性乙型肝炎（CHB）组60例，
重型慢性肝炎组40例。选取同期于本院接受健康检查的正常人群20例为健康对照组。检测干扰素治疗
前、治疗后4周、12周、24周、48周时外周血T淋巴细胞趋化因子受体（CXCR3、CCR6）及血清趋化
因子水平（CXCL9、CXCL11、CCL20）、HBsAg、HBV DNA和ALT水平。结果 CHB组、慢性重型
肝炎组及健康对照组间CXCR3、CCR6、CXCL9、CXCL11、CCL20表达差异有统计学意义（F值分别
为2.067、2.914、4.791、2.582、3.802，P值分别为0.043、0.031、0.011、0.034、0.024）。干扰素治疗
12周、24周、48周后CHB患者血清HBV DNA、HBsAg、ALT均有不同程度下降，T细胞趋化因子受体
及血清趋化因子的表达下调，与治疗前比较差异有统计学意义（P 均＜ 0.05），但治疗4周时与治疗
前比较差异无显著统计学意义（t值分别为1.23、0.74、1.64，P值分别为0.063、0.481、0.051）。结论
CXCR3、CCR6及其配体（CXCL9、CXCL11、CCL20）参与了HBV感染后肝脏损伤，干扰素治疗可
以影响CXCR3、CCR6及其配体（CXCL9、CXCL11、CCL20）的表达水平。

Abstract: Objective To investigate the influence of antiviral therapy on the expression of T lymphocytes
chemokine receptors and serum chemokines in patients with chronic hepatitis B. Methods Total of 100
patients with hepatitis in Chengdu Public Health Clinical Medical Center from May 2012 to December 2012
were selected and divided into CHB group and chronic severe hepatitis group. Among the patients, 68 cases
were male and 32 cases were female, the average age was (54.6 ± 4.3) years (34～72 years) old. The serum
HBV DNA, HBsAg, ALT, chemokines (CXCL9, CXCL11, CCL20) and T lymphocytes chemokine receptors
(CXCR3, CCR6) were detected before and after the interferon treatment for 4 weeks, 12 weeks, 24 weeks,
and 48 weeks. Total of 20 healthy persons who accepted health examination in our hospital were selected as
the healthy control. Results Among the CHB group, chronic severe hepatitis group and the healthy control
group, the expression of T lymphocytes chemokine rceptors (CXCR3, CCR6) and serum chemokines
(CXCL11, CXCL9, CCL20) had significant difference (F = 2.067, 2.914, 4.791, 2.582, 3.802; P = 0.043, 0.031,
0.011, 0.034, 0.024, respectively). The serum HBV DNA, HBsAg, ALT, chemokines and T lymphocytes
chemokine receptors had declined significantly after the interferon treatment for 12 weeks, 24 weeks, 48
weeks (P ＜ 0.05), and for 4 weeks, there was no statistical difference (t = 1.23, 0.74, 1.64; P = 0.063, 0.481,
0.051, respectively). Conclusions CXCR3, CCR6 and the ligands (CXCL9, CXCL11, CCL20) were involved
in HBV-related liver damage. Interferon therapy can influence the expression levels of CXCR3, CCR6 and the
ligands (CXCL9, CXCL11, CCL20).

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