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乙型肝炎、丙型肝炎合并EB病毒感染与肝硬化发生的横断面研究

作者：杨玉奇 1 张慧 2 李昕 2 王冰 2 刘子杰 2

单位：1.大理市第二人民医院检验科云南大理 671003 2.昆明医科大学第一附属医院检验科昆明 650031

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出版年,卷(期):页码：2015,7(4):90-93

摘要：

摘要：目的探讨EB病毒（epstein-barr virus，EBV）感染对乙型肝炎、丙型肝炎肝硬化的影响。方
法选取2014年1月至2014年6月昆明医科大学第一附属医院确诊的乙型肝炎和丙型肝炎患者424例。乙
型肝炎病毒（hepatitis B virus，HBV）感染者306例，其中合并EB病毒感染者130例，乙型肝炎肝硬
化141例；丙型肝炎病毒（hepatitis C virus，HCV）感染者118例，其中合并EB病毒感染者66例，丙
型肝炎肝硬化41例。以卡方检验分析乙型肝炎、丙型肝炎患者合并EB病毒感染与肝硬化的相关性。
以Logistic回归调整抗病毒治疗史、饮酒、病程、性别、年龄、乙型肝炎、丙型肝炎病毒载量后分析
EB病毒与肝硬化的相关性，采用Mann-Whitney检验分析ALT、AST、ALT/AST、TBA、TBil、DBil在
不同组间的差异。结果卡方检验结果表明EB病毒与丙型肝炎肝硬化有显著相关性（P = 0.018），与
乙型肝炎无显著相关性（P = 0.342）。经Logistic回归调整后EB病毒与丙型肝炎肝硬化仍有一定相关
性（P = 0.05）。Mann-Whitney检验结果发现乙型肝炎和肝硬化及丙型肝炎与肝硬化组比较，ALT、
ALT/AST、TBA、TBil、DBil差异有显著性，而与EB病毒感染无关。结论 EB病毒感染与丙型肝炎
肝硬化有一定相关性，乙型肝炎与丙型肝炎患者是否感染EB病毒对ALT、AST、ALT/AST、TBA、
TBil、DBil无明显影响。

Abstract: Objective To investigate the relationship between hepatitis B/C co-infected with epstein-barr virus
(EBV) and liver cirrhosis. Methods Total of 424 patients with hepatitis B and C from January 2014 to June
2014 in the First Affiliated Hospital of Kunming Medical University were studied, among whom 306 patients
were infected with HBV, 130 out of the 306 patients were co-infected with EBV, and 141 of them were with
liver cirrhosis. Total of 118 patients were infected with hepatitis C virus, 66 patients were co-infected with
EBV, and 41 of them were liver cirrhosis. The Chi-square test was used to determine the relationship between
EBV and hepatitis B/C. Alcohol intake, medical duration, gender, age and viral load adjusted with Logistic
regression method was used to analyze the correlation of EB virus and liver cirrhosis. Mann-Whitney test was
applied to analyze variations of ALT, AST, ALT/AST, TBA, TBil and DBil in different groups. Results Chi-
square test result indicated that there was a significant relationship between liver cirrhosis patients co-infected
with EB virus and hepatitis C virus (P = 0.018). However, no significant difference was observed between EB
virus and liver cirrhosis (P = 0.342), but there was still a correlation after adjusted with Logistic regression
(P = 0.05) for hepatitis C patients co-infected with EB virus. Mann-Whitney test showed large diversities of
ALT, AST, ALT/AST, TBA, TBil, DBil results between liver cirrhosis and hepatitis B/C groups. Conclusion
There was a relationship between hepatitis C patients co-infected with EBV virus and liver cirrhosis, but EB
virus dose not influence ALT, AST, ALT/AST, TBA, TBil, DBil in hepatitis B/C patients.

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