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慢性乙型重症肝炎预后的影响因素

作者：杨启胡蓉曾义岚张琼毛创杰

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出版年,卷(期):页码：2015,7(4):94-96

摘要：

摘要：目的探讨慢性乙型重症肝炎患者预后的影响因素。方法回顾性分析2014年6月至2015年2月就
诊于成都市公共卫生临床医疗中心的慢性乙型重症肝炎患者197例，将治疗后好转的132例患者作为对
照组，治疗后恶化死亡的65例患者作为观察组，观察两组患者合并饮酒史，凝血酶原时间延长、甲胎
蛋白动态变化、乙型肝炎病毒载量变化的差异。结果两组患者合并饮酒史（P = 0.003）、凝血酶原时
间延长（P = 0.032）、甲胎蛋白动态变化（P = 0.001）、乙型肝炎病毒载量变化存在显著性差异（P =
0.007）。结论合并饮酒史、凝血酶原时间延长、甲胎蛋白缺乏动态变化、乙型肝炎病毒载量降低速
率慢均影响慢性乙型重症肝炎患者的预后。

Abstract: Objective To explore the influence factors of prognosis of chronic severe hepatitis B. Methods
Total of 197 patients with chronic severe hepatitis B from June 2014 to February 2015 in Public Health Clinical
Center of Chengdu were retrospectively analyzed. All the patients were divided into two groups, 132 cases
improved after treatment were in control group and 65 patients who died of deterioration were in observation
group. The duration of the combination, the extension of prothrombin time, the dynamic changes of alpha
fetoprotein, and the changes of HBV DNA load of the two groups were observed and compared. Results
There were significant differences in the changes of alcohol consumption (P = 0.003), prothrombin time (P =
0.032), the dynamic changes of the fetal protein (P = 0.001) and HBV DNA load (P = 0.007) in both groups.
Conclusion The alcohol intake, prothrombin time prolonged, AFP lack of dynamic changes, and hepatitis B
virus load decreased slowly are the influence factors of the prognosis of chronic severe hepatitis.

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