Abstract: Mitochondria is an important cell organelle which is involved in energy metabolism, cell apoptosis,
immune regulation and cell cycle regulation. In hepatitis B virus (HBV) pathogenesis, HBV interact with
mitochondria through HBx and HBsAg. HBV may act on the mitochondria related intrinsic apoptosis, but
the results are different in different situations. Besides, HBV is also related to oxygen stress injury, cell cycle
regulation and antiviral immune response. Effect of HBV on mitochondria is to build the circumstance for
HBV life cycle and cause liver injury. Further studies are needed to elucidate the role of mitochondria in HBV
pathogenesis.