Abstract: In the natural history of chronic hepatitis B virus (HBV) infection, the immune tolerance (IT)
phase represents the classical early phase of infection, which plays a decisive role in the monitoring and
treatment. In order to explore the mechanism of IT and find effective treatment methods, a large numbers of
studies have been published based on the connection between the virus and the host. The immunodeficiency
of host may act as a significant mechanism of IT, that is why T cells involved in the immune response plays
an important role in CHB infection of IT.