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门冬氨酸鸟氨酸颗粒防治肿瘤化疗引起药物性肝功能损伤的临床研究

作者：蔡小鹏张春晓苏飞宋海滨

单位：武汉大学中南医院肿瘤科武汉 430071

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出版年,卷(期):页码：2016,8(1):90-93

摘要：

摘要：目的观察门冬氨酸鸟氨酸颗粒对恶性肿瘤术后化疗患者的肝功能损伤保护作用。方法选择110
例恶性肿瘤术后需行系统化疗的患者，将其随机分为试验组（55例）和对照组（55例），试验组给
予门冬氨酸鸟氨酸颗粒治疗，对照组化疗期间不使用护肝治疗。观察化疗后肝损伤的发生率，化疗
前后天门冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）和总胆红素（TBil）的变化以及化
疗后肝损伤程度。结果试验组中化疗药物肝功能损伤发生率显著低于对照组（22.8% vs 61.8%，P ＜
0.001）。试验组化疗结束后AST、ALT和TBil的平均数值[（40.5 ± 26.1）U/L，（45.7 ± 25.4）U/L，
（14.7 ± 11.2）μmol/L]均显著低于对照组化疗后的平均数值[（92.3 ± 48.2）U/L，（94.2 ± 37.4）U/L，
（44.1 ± 26.5）μmol/L）]，两组中的3项指标对比差异均有统计学意义（P值分别为0.003、0.010、
0.047）。试验组药物性肝功能损伤的严重程度低于对照组（P ＜ 0.001）。结论门冬氨酸鸟氨酸颗粒
可以降低患者因化疗导致的肝功能损伤发生。

Abstract: Objective To evaluate the effects of ornithine aspartate (OA) on protecting liver function from the
impairment of chemotherapy drugs for malignant tumors. Methods Total of 110 postoperative patients who
needed chemotherapy were selected and randomly divided into experimental group and control group, 55 cases
in each group. The experimental group were given chemotherapy combined with OA and the control group were
given chemotherapy only. Both of the two groups received 4 period of chemotherapy, AST, ALT and TBil were
detected every two weeks. Rsults The rate of liver function impairment in experimental group was significantly
lower than that of the control group (22.8% vs 61.8%, P ＜ 0.001). After the whole chemotherapy, the levels
of AST, ALT and TBil in experimental group [(40.5 ± 26.1) U/L, (45.7 ± 25.4) U/L, (14.7 ± 11.2) μmol/L)] were
significantly lower than those in control group [(92.3 ± 48.2) U/L, (94.2 ± 37.4) U/L, (44.1 ± 26.5) μmol/L)], (P =
0.003, 0.010, 0.047, respectively). The severity of liver function impairment in experimental group was also lower
than that in control group (P ＜ 0.001). Conclusion Ornithine Aspartate could protect the liver function from the
impairment of chemotherapy drugs in patients underwent radical surgery.

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