Abstract: Acute liver failure is a severe clinical syndrome which is lack of effective treatment, therefore,
it is urgent to seek a new effective therapy. At present, a large numbers of studies have identified that
mesenchymal stem cells have a therapeutic effect on acute liver failure. This review summarized the
mechanisms of the mesenchymal stem cells in treatment of acute liver failure from the aspect of anti-
inflammatory, anti-apoptosis, immune refulation and anti-oxidation in recent years. And it also summarized
the methods which were aimed to improve the therapeutic effect of mesenchymal stem cells.