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自身免疫性肝炎Ⅰ型患者自身抗体与血清生物化学指标的相关性分析

作者：刘玲 1 李晓东 2 肖明中 2 赵友云 1 彭晓明 1

单位：1.湖北省中医院检验科武汉 430061 2.湖北省中医院肝病科武汉 430061

关键词：肝炎自身免疫性自身抗体生物化学指标相关性

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出版年,卷(期):页码：2016,8(2):14-18

摘要：

摘要：目的探讨自身免疫性肝炎（autoimmune hepatitis，AIH）Ⅰ型患者自身抗体与其血清生物化
学指标的相关性。方法选取2010年12月至2014年12月于湖北省中医院就诊的163例AIH-Ⅰ型患者为
研究组，另外纳入197例健康献血者为对照组，采用酶联免疫法（ELSIA）检测AIH-Ⅰ型患者的抗核
抗体（antinuclear antibody，ANA）、抗纤维肌动蛋白抗体（anti-filamentous actin antibody，AFA）
和抗平滑肌抗体（anti-smooth muscle antibody，ASMA），采集全部研究对象的血清进行生物化学指
标（ALT、AST、ALP、TBil、γ-GT、GLO）和免疫球蛋白（IgG、IgA、IgM）的检测，应用SPSS
l9.0统计软件对检测结果进行统计学分析。结果 AIH-Ⅰ型患者ANA、AFA和ASMA的阳性率分别为
84.66%、75.46%和70.55%。与对照组相比，AIH-Ⅰ型患者生物化学指标除ALP外，其他均显著升
高。AIH-Ⅰ型患者的ANA与AST、TBil低度相关，AFA与ALT、AST和IgG低度相关，ASMA与ALT、
AST和IgM低度相关。结论 AIH-Ⅰ型患者自身抗体ANA、AFA、ASMA与其血清生物化学指标的相关
性较差，二者对AIH-Ⅰ的诊断价值不能相互替代。

Abstract: Objective To investigate the correlation of autoantibodies and biochemical indicators in patients
with autoimmune hepatitis (AIH) type Ⅰ. Methods Total of 163 patients with AIH-Ⅰ from December
2010 to December 2014 in Hubei Provincial Hospital of Traditional Chinese Medicine were selected as the
research group and other 197 blood donors were selected as the controls. The antinuclear antibody (ANA),
anti-filamentous actin antibodies (AFA) and anti-smooth muscle antibodies (SMA) in patients with AIH-Ⅰ
were evaluated by ELISA and the serum biochemical indicators in patients with AIH-Ⅰ type and the controls
were detected, all the results were analyzed by SPSS 19.00 software. Results The positive rates of ANA, AFA
and ASMA in patients with AIH-Ⅰ type were 84.66%, 75.46% and 70.55%, respectively. Except for ALP,
the biochemical indicators were significantly higher in patients with AIH-Ⅰ than those of the controls. The
ANA was lowly correlated with AST and TBil, the AFA was lowly correlated with ALT, AST and IgG and the
ASMA was lowly correlated with ALT, AST and IgM. Conclusions The autoantibodies including ANA, AFA
and ASMA have a low correlation with biochemical indicators in patients with AIH-Ⅰ, and the diagnostic
value of autoantibodies and biochemical indicators can not be replaced by each other.

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