Abstract: Objective To investigate the therapeutic effect of induced pluripotent stem cells (IPS cells) on liver
injury. Methods Total of 28 healthy male C57 mice were divided into healthy control group, experimental
group and experimental control group. In the experimental group, a mouse liver injury model was induced by
intraperitoneal injection of amino galactose (2500 mg/kg). After two days, the IPS cells were injected into the
mice in the experimental group with fluorescence labeled CFSE. After 5 days, 10 days, 15 days and 20 days,
the mice in healthy control group, experimental group and experimental control group were sacrificed and
the liver samples were taken for frozen section and paraffin sections were stained with HE staining. The liver
function were detected. Results The IPS cells can be settled in the liver of the mice after injection. ALT and
AST in the blood of mice after injecting with IPS cells decreased significantly faster than those in the non IPS
cells and the recovery of liver pathological injury improved significantly. Conclusion IPS cells can repair the
damage of liver after injected into the C57 mice with liver injury.