Abstracts: Objective To discuss the curative effects of probiotics combined with adefovir dipivoxil in
treatment of patients with HBV-related cirrhosis and the effects on immune function. Methods Total of
104 cases of hepatitis B with liver cirrhosis were selected and randomly divided into observation group and
control group, 52 cases in each group. Patients in observation group were given probiotics Bifid Triple Viable
capsule combined with adefovir dipivoxil for 6 months orally, and patients in control group were only given
adefovir dipivoxil for 6 months. The biochemical indicators, mainly including routine blood, HBV DNA
levels, liver fibrosis indicators, ALT, AST, ALB and TBil were detected. Results After 6 weeks’ treatment,
the effective rate of the observation group (88.46%) was higher than that of the control group (71.15%),
the difference was statistically significant (χ 2 = 4.83, P = 0.03). The liver functions of the two groups both
improved significantly, the ALT, AST and TBil levels of the observation group were lower than those of the
control group, the ALB level was lower than that of the control group, and the differences were statistically
significant (t = 4.26, 12.90, 6.97, 15.09; P = 0.04, 0.004, 0.02, 0.00). The CD4 + , CD4 + /CD8 + and NK levels
of the observation group were significantly higher than those of the control group, and the CD8 + level was
significantly lower than that of the control group, and the differences were statistically significant (t = 4.39,
14.09, 7.64, 6.90; P = 0.04, 0.01, 0.014, 0.03). Conclusions The curative effects of probiotics combined with
adefovir dipivoxil in treatment of hepatitis B patients with liver cirrhosis is better than single use, which has
the advantages of improving immune function and liver function, and can improve the treatment effect.