Abstract: Objective To evaluate the effects of intrahepatic cholestasis of pregnancy (ICP) on the pregnancy
outcomes and the complications of pregnant women with hepatitis B virus (HBV) infection. Methods Total
of 88 ICP patients with HBV infection (ALT and AST were normal) from January 2013 to July 2015 in
Beijing Ditan Hospital, Capital Medical University were selected as the study group, and 1206 cases of HBV
infection pregnant women with normal liver functions were selected as the control group. The incidence rate
of gestational diabetes mellitus (GDM), the rate of premature delivery, neonatal asphyxia, cesarean section,
postpartum hemorrhage and other complications between the two groups were compared. Results The rate
of premature delivery, cesarean section and postpartum hemorrhage in the study group were 14.8%, 68.18%
and 7.95%, respectively. The IVF-ET composition ratio and twins pregnancy rate were statistically significant
between the two groups (P = 0.004, 0.000). The weight of premature baby in study group was significantly
lower than that of control group. GDM occurrence and neonatal asphyxia rate had no statistically significant
difference between the two groups (P = 0.460, 0.891). Conclusion ICP patients with HBV infection can
easily cause premature and postpartum hemorrhage, and can increase the chance of operation and reduce the
birth weight of premature.