Abstract: Objective To investigate the effects of different status of hepatitis B virus (HBV) infection on the
incidence and pregnancy outcomes of intrahepatic cholestasis of pregnancy. Methods Pregnant women who
were delivered in Beijing Ditan Hospital, Capital Medical University with or without HBV infection from
November 2011 to January 2015 were collected. They were divided into three groups: HBV carriers (group
A), chronic hepatitis B (group B), and patients without HBV infection (group C). The incidence of ICP and
pregnancy outcomes were compared. Results Total of 7627 pregnant women who met the requirements were
collected, 3860 cases were in group A, 1566 cases were in group B and 2201 cases were in group C. The
incidence of ICP in the three groups were 1.32% (51/3860), 6.9% (108/1566) and 2.45% (54/2201), respectively.
The time of pruritus onset, TBil level, incidence of premature delivery and the weight of infants had statistically
significant difference among the three groups (P = 0.036, 0.031, 0.021, 0.039). The rate of neonate asphyxia
was 2.8% in ICP patients with chronic hepatitis B. The rate of bleeding (≥ 300 ml/24 h) after delivery in three
groups were 3.9%, 4.6% and 1.8%, respectively, with statistically significant difference (χ 2 = 9.432, P = 0.024).
Conclusions Pregnant women with chronic hepatitis B have a higher incidence of ICP, an earlier onset of
pruritus and a higher rate of jaundice, premature delivery and postpartum hemorrhage. Monitoring and treatment
should be strengthened for patients with HBV infection and attentions on neonate asphyxia should be payed .