Abstract: Objective To explore the significance of serum ferritin in patients with non-alcoholic fatty liver disease
(NAFLD). Methods Serum ferritin levels among 250 patients with NAFLD were detected by microparticle
enzyme immunoassay (MEIA). The patients were divided into mild group (65 cases), moderate group (98 cases)
and severe group (87 cases) according to the first diagnosis of CT. The serum ferritin values were compared among
the three groups. Results Total of 135 cases among the 250 patients with NAFLD were with normal ALT, and the
mean value of SF was (320.5 ± 167) ng/ml; 115 patients were with abnormal ALT, the mean value of SF was (608.5
± 254.4) ng/ml, and the difference was statistically significant (z = 10.38, P = 0.00). The ALT values in mild group,
moderate group and severe group were (87.2 ± 52.0) U/L, (99.4 ± 68.5) U/L and (89.4 ±78.0) U/L, respectively,
and there were no statistical differences among the three groups (z = 0.18，P = 0.43). The SF values in the three
groups were (330.5 ± 118.0) ng/ml, (350.2 ± 187.5)ng/ml and (509.4 ± 150.8) ng/ml, respectively, and there was no
significant difference between mild and moderate group; SF was significantly higher in severe group than that of
the mild and moderate group (z = 8.20, 6.39; P = 0.00). Conclusion The increase of SF in patients with NAFLD is
closely related to the degree of hepatic steatosis and hepatic cell damage.