Abstract: Objective To investigate the predictive value of early blood lactate and lactate clearance on
prognosis evaluation in patients with chronic liver failure. Methods The clinical data of patients with chronic
liver failure in the Fifth Affiliated Hospital of Kunming Medical University were studied prospectively. The
blood lactate levels at 0 h, 12 h and Child-Pugh score were measured respectively. The relationships between
early blood lactate level, lactate clearance rate, Child-Pugh scores and the 28-day mortality were analyzed.
Results Total of 76 patients with chronic liver failure were selected. The 28-day mortality was 52.63%. The
blood lactate level in death group at 0 h, 12 h and Child-Pugh score were higher than those in survival group
(P = 0.00045, 0.00033, 0.0071). The correlation between early blood lactate and Child - Pugh score was
significant (P = 0.041, 0.047). The lactate clearance rate at 12 h in survival group was significantly higher
than that of death group (P = 0.00024). Multivariate logistic regression analysis showed that the blood lactate
at 0 h, 12 h and the lactate clearance rate at 12 h were independent predictive factors of prognosis evaluation.
Conclusions For patients with chronic liver failure, early dynamic monitoring arterial blood lactic level is of
great significance. Blood lactate level at 0 h, 12 h and the lactate clearance rate at 12 h have practical clinical
value for prognosis of patients with chronic liver failure.