Abstract: Clinical data of 3 cases of low-dose adefovir dipivoxil induced hypophosphataemic osteomalacia
were retrospectively analyzed. We found that kidney and bone toxicity should be paid attention to in the long
term use of adefovir in patients with chronic hepatitis B. Closely observation of clinical manifestations and
regularly monitoring of blood phosphorus, alkaline phosphatase, renal function and other indicators were
needed so as to avoid the misdiagnosis and wrong treatment.