Abstract: Chronic liver diseases associated with cirrhosis variceal bleeding and hepatocellular carcinoma,
which lack clinical treatment, have a poor outcome. Recent research have indicated that angiogenesis
played an important part in the development of chronic liver disease. Placental growth factor was only
involved in pathological angiogenesis, which therefore would be an obvious advantage as a potential anti-
angiogenic target. Here we make a review of the role of placental growth factor in chronic liver diseases
and hepatic angiogenesis.