Abstract: Objective To analyze the level of serum globulin (GLO) and alpha fetoprotein (AFP) in patients
with hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF) and the effects on prognosis,
retrospectively. Methods Total of 104 patients with HBV-ACLF from July 2013 to June 2015 in our hospital
were selected and divided into survival group (48 cases) and death group (56 cases). Levels of GLO, AFP
and serum total protein (STP) were detected and the correlation with the prognosis were analyzed. The
serum level of GLO in survival group was (18.36 ± 2.97) g/L, which was lower than that of the death group
[(32.08 ± 3.02) g/L], the difference was statistically significant (t = 9.42, P = 0.04). The levels of STP in
both groups had no statistically significant difference (t = 3.17, P = 0.08). The serum level of AFP in survival
group was (324.96 ± 27.84) μg/L, which was higher than that of the death group [(168.23 ± 25.70) μg/L],
the difference was statistically significant (t = 12.38, P = 0.01). Results The incidence rate of ascites, upper
gastrointestinal bleeding, hepatic encephalopathy, hepatorenal syndrome, electrolyte disorders and death in
patients with GLO ≥ 30g/L and AFP ＜ 200 μg/L were higher than those in patients with GLO ＜ 30g/L
and AFP ≥ 200 μg/L, the differences were statistically significant (P ＜ 0.05). Conclusions The serum level
of AFP decreased and GLO increased in death group. Prognosis like ascites, upper gastrointestinal bleeding,
hepatic encephalopathy, hepatorenal syndrome, electrolyte disorder and death are related with the levels of
GLO and AFP. Detection of the levels of GLO and AFP are helpful to the assessment of complications and
prognosis of the patients.