Abstract: This paper reported one case that HBV transmission from chronic hepatitis B mother to infant
was interrupted successfully by antiviral therapy with telbivudine to the couple who with HBeAg-positive
during the whole perinatal period and hepatitis B immune globulin combined hepatitis B vaccine was given
to the baby. It reminds that antiviral therapy to supplemented the traditional prevention of mother-to- child
transmission has clinical significance.