Abstract: A 30-year-old male patient with chronic hepatitis B who suffered with recurrent fever during the
period of treatment with a combination of subcutaneous injection of pegylated interferon α-2b and intravenous
drip of Salvia miltiorrhiza injection was diagnosed as drug fever caused by Salvia miltiorrhiza injection after
careful observation and examination. Stopping the use of Salvia miltiorrhiza injection but continuous use of
interferon alone resulted in the recovery of normal body temperature of the patient. This normal temperature
was keeping during the follow-up time of 8 months. This suggests that drug fever caused by traditional
Chinese medicine injection should be paid more attention and should not arbitrarily be diagnosed as influenza-
like syndrome caused by pegylated interferon α-2b.