Abstract: Circular RNA (circ RNAs) is a novel type of non-coding RNA (ncRNA) and competing
endogenous RNA (ceRNA), who forms covalently closed loop structure by jointing 3’ and 5’ ends together
via exon circularization and intron circularization. Current studies have discovered that circRNAs are widely
expressed in eukaryocyte and act as regulator of gene expression by interacting with miRNA, proteins and
other molecules. Emerging evidence indicates that circRNA plays the essential role in the development
of some diseases and may serve as diagnostic or predictive biomarkers. Herein, we reviewed the current
available outcomes and progress of researches concerning circRNAs and the potential relationship between
HBV-related liver diseases and circRNAs.