Abstract: Objective To investigate the effects of terlipressin combined with alprostadil on liver and renal
function of patients with intractable ascites of cirrhosis. Methods Total of 56 patients with intractable ascites
of cirrhosis from December 2014 to August 2015 in our hospital were randomly selected and divided into
observation group and control group, 28 cases in each group. Patients in observation group were treated
with terlipressin combined with alprostadil on the basis of traditional treatment which included traditional
dietary guidelines, sodium restriction and water intake, hepatoprotective and diuretic methods, while patients
in control group were only given traditional treatment. The function of liver and renal in both groups were
observed after treatment for 21 days. Results Before treatment, the differences of liver and renal function
between the two groups had no statistical significance (P ＜ 0.05). After treatment, the ascites volume
of patients in observation group decreased significantly, and the function of liver and renal improved
significantly (P ＜ 0.05). Conclusion Erlipressin combined with alprostadil can effectively reduce the ascites
and improve liver and kidney function of patients with intractable ascites of cirrhosis.