Abstract: For patients with end-stage liver failure, liver transplantation is the most direct and effective
treatment options. However, there are many problems that are difficult to be solved in liver transplantation,
such as high cost of operation, shortage of donors and long-term use of immunosuppressive drugs, which led
to the death of patients. In recent years, the study of mesenchymal stem cells (MSCs) provides a new way
to the treatment of many diseases, especially in the treatment of end-stage liver diseases, which has great
development and application prospects and is the gospel for patients with end-stage liver diseases. Currently,
as an ideal cell transplantation and gene therapy seed cells, the research of mesenchymal stem cells are highly
concerned. In this paper, the research progress of mesenchymal stem cell transplantation in the treatment of
end-stage liver failure is reviewed.