Abstract: Objective To evaluate the value of sound speed correction (SSC) in the quantitative diagnosis
of nonalcoholic simple fatty liver (NAFL). Methods Total of 26 patients with NAFL were selected as
NAFL group and 37 healthy controls were selected as control group. SSC, the zone speed index (ZSI), zone
sound speed (ZSS) of hepatic segments s5～s8 and hepatic central area were measured. At the same time,
the inclined diameter of the right hepatic lobe and the portal vein’s diameter were measured. Results The
ZSS of hepatic segments s6～s7 in NAFL group were higher than those of control group, the differences
were statistically significant (P ＜ 0.05). However, the ZSS of hepatic segments s5 and s8 had no statistical
differences between two groups (P ＞ 0.05). In NAFL group, ZSI and inclined diameter of the right hepatic
lobe was positively correlated (r = 0.42，P = 0.032), and the regression equation is y = 0.84x -103.1.
Conclusions SSC has certain value in quantitative diagnosis of NAFL, and it is worthy of further research for
accurate classification of the degree of NAFL.