Abstract: Objective To investigate the clinical significance of serum CA125 in cirrhotic patients with
ascites, and to evaluate the value of CA125 as the biomarker of ascites. Methods Clinical data of 461 cases
with liver cirrhosis from June 2015 to December 2015 in our hospital were retrospectively analyzed. All the
patients were divided into non ascites group, little ascites group and middle to large ascites group according
to the amount of ascites. Spearman’s rank correlation and receiver operating characteristic (ROC) curve were
used to analyze the clinical significance of CA125 in liver cirrhosis patients with ascites. Results Serum
CA125 level was positively correlated with the degree of ascites (ρ = 0.803，P ＜ 0.0001). The cut-off value
of CA125 in ascites qualitative analysis was 34.7 U/ml, and the AUROC, sensitivity, specificity, positive
likelihood ratio and negative likelihood ratio were 0.958, 88.5%, 95.3%, 18.83 and 0.12, respectively. The cut-
off value of CA125 in ascites quantitative analysis was 72.2 U/ml, and the AUROC, sensitivity, specificity,
positive likelihood ratio and negative likelihood ratio were 0.801, 62.5%, 87.5%, 5.00, and 0.43, respectively.
Conclusion The serum CA125 might be used as a biomarker in prediction of short-term outcome of liver
cirrhosis patients with ascites.