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成人麻疹肝损伤药物治疗及临床特征

作者：郝润来李建明唐中权

单位：呼和浩特市第二医院五病区呼和浩特 010031

关键词：麻疹肝功能损伤成人异甘草酸镁临床特征治疗

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出版年,卷(期):页码：2017,9(2):70-73

摘要：

摘要：目的探讨成人麻疹肝损伤治疗的有效药物与临床特征。方法对56例成人麻疹肝损伤患者进行
回顾性分析，随机分为对照组和观察组。对照组26例，给予多烯磷脂酰胆碱0.465 g/d；观察组30例，
给予异甘草酸镁150 mg/d，静脉滴注，每日1次，疗程均不超过4周。观察患者ALT、AST和TBil水平的
变化。结果所有患者治疗前ALT、AST、TBil异常率分别为100.0%、85.7%和5.4%，其中轻中度损伤分
别占96.4%、100.0%和100.0%。治疗1周后，对照组和观察组患者肝功能复常率分别为46.2%和76.7%，
差异有统计学意义（χ 2 = 4.158、P = 0.041）。对照组和观察组患者的住院时间分别为（10.78 ± 2.21）
天和（8.02 ± 1.67）天，差异有统计学意义（t = 2.712、P = 0.026）。结论成人麻疹肝损伤临床特征明
显，异甘草酸镁治疗麻疹肝损伤效果优于多烯磷脂酰胆碱。

Abstract: Objective To investigate the effective drugs and clinical features of liver damage in adults with
measles. Methods Total of 56 measles cases with liver injury were randomly divided into the control group (26
cases) and observation group (30 cases). Patients in control group were given polyene phosphatidyl choline 0.465
g/d and patients in observation group were given magnesium isoglycyrrhizinate 150 mg/d. The courses were no
more than 4 weeks. The levels of ALT, AST and TBil were observed. Results The abnormal rates of ALT, AST
and TBil before treatment were 100.0%, 85.7% and 5.4%, respectively. The moderate damage rates were 96.4%,
100.0% and 100.0%, respectively. After treatment for 1 week, the liver function resuming rates of patients
in control group and observation group were 46.2% and 76.7%, respectively, the difference was statistically
significant (χ 2 = 4.158, P = 0.041). The hospitalization time of patients in control group and observation group
were (10.78 ± 2.21) days and (8.02 ± 1.67) days, the difference was statistically significant (t = 2.712, P =
0.026). Conclusion Adult measles has obvious clinical characteristics of liver injury. The effects of magnesium
isoglycyrrhizinate is better than polyene phosphatidyl choline in treatment of liver damage caused by measles.

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