Abstract: To explore the clinical features of hepatocellular carcinoma (HCC) with acute febrile as initial
symptoms by analyzing 4 cases of febrile hepatocellular carcinoma. The results showed that febrile
hepatocellular carcinoma has a high misdiagnosis rate. The causes of fever is related to cancerous fever
and infection. AFP, PIVKA, PCT, imaging and pathology examination of liver were the important ways
to determine the causes of fever. The therapeutic principle of febrile hepatic carcinoma is the same as
hepatocellular carcinoma.