Abstract: Hepatitis B virus X (HBx) protein trans-activate gene XTP4 is a new gene found in recent years,
which is related to the development of tumor. Many studies showed that XTP4 gene is abnormally expressed
in breast cancer, prostate cancer, gastric cancer, colorectal cancer, ovarian cancer, non-small cell lung cancer,
hepatocellular carcinoma and other abnormal tumor. The abnormal expression of XTP4 gene is closely related
to cell hyperplasia, metastasis, invasion, tumor grade, staging and chemotherapy resistance. In view of the
XTP4 gene playing an important role in various types of tumors or different stages of tumors and in order to
facilitate the latter part of its function in-depth study, this paper will clarify the relationship of XTP4 gene
structure, function and tumor occurrence and development.