中国肝脏病杂志(电子版)

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基于“精准医疗”理念的HBV母婴传播阻断

作者：雷雨 1 2 刘园园 1 刘龙 1 谭华炳 1

单位：1.湖北医药学院附属人民医院肝病研究所湖北十堰 442000 2.房县人民医院感染性疾病科湖北房县 442100

关键词：肝炎病毒乙型母婴传播宫内感染抗病毒精准阻断

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出版年,卷(期):页码：2017,9(3):22-25

摘要：

摘要：我国是HBV感染高发地区，由HBV感染引起的肝硬化（liver cirrhosis，LC）和肝细胞癌
（hepatocellular carcinoma，HCC）分别占LC和HCC的60%和80%，我国HCC患者占世界HCC患者的
53.5%。我国HBV感染约一半是通过母婴传播形成的。因此，阻断HBV母婴传播具有重要意义。本
文通过综述HBV DNA载量、HBV基因型、HBV耐药、ALT和AST与母婴传播的关系，应用“精准医
疗”的理念，提出了以HBV宫内感染为基础的精准阻断理念，以期为进一步科学阻断HBV母婴传播
提供参考。

Abstract: China has a high prevalence of hepatitis B virus (HBV) infection. Liver cirrhosis (LC) and
hepatocellular carcinoma (HCC) caused by HBV infection accounted for 60% and 80% of all HC and HCC
patients, respectively. Patients with HCC in China accounted for 53.5% of the world. Half of patients with
HBV infection were transmitted through mother-to-child route. Blocking mother-to-child transmission of
HBV has important social and economic significance. This review summarized the relationship between
HBV DNA load, viral genotype, drug resistance, chronic hepatitis activity and mother-to-child transmission.
Referring to the precision medicine, we proposed the precision concept of blocking mother-to-child
transmission based on HBV intrauterine infection, in order to provide theoretical basis for further study of
blocking HBV mother-to-child transmission.

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