Abstract: Hedgehog signaling pathway is a highly conserved signaling pathway which plays important roles
on cell proliferation, cell adhesion, cell migration, cell differentiation and embryo formation in the regulation
of embryonic development and growth. Hedgehog signaling pathway is also involved in wound healing of
many mature organs, especially in the repair of liver injury. However, excessive activation of Hedgehog
signaling pathway can lead to liver fibrosis and hepatocellular carcinoma. This review summarized the
mechanism of Hedgehog signaling pathway in liver diseases so as to provide a theoretical basis for tumor
targeting therapy and inflammatory injury repairs.