Abstract: Nuclear factor-associated factor 2 (Nrf2) is a key transcription factor that regulates the oxidative
damage and the expression of antioxidants by oxidizing the original (ARE) in cells. Under oxidative stress,
Nrf2 is activated and can induce the expression of antioxidant enzymes such as heme oxygenase-1 (HO-1) in
the downstream tissues. Nrf2 has a protective effect in liver injury, fatty liver, liver fibrosis and liver cancer
and other chronic liver disease through its anti-inflammatory, anti-oxidation and regulation of apoptosis
and other mechanisms. In this paper, the research progress of Nrf2/HO-1 signaling pathway in chronic liver
disease in recent years were summarized to provide the theoretical basis for exploring the pathogenesis of
chronic liver disease and finding new target therapy.