Abstract: Objective To evaluate the value of Swansea diagnostic criteria in the diagnosis of patients with
acute fatty liver of pregnancy (AFLP) in China. Methods The clinical data of patients discharged with AFLP
in Beijing Ditan Hospital, Capital Medical University from January 1996 to March 2017 were retrospectively
analyzed by using Swansea diagnostic criteria. The accuracy of Swansea diagnostic criteria for AFLP
diagnosis, the major complications of maternal and fetus and the incidence of blood purification therapy at
different score thresholds were evaluated. Results From January 1996 to March 2017, a total of 70 patients
were diagnosed with AFLP. There were 65 cases (92.8%) whose Swansea diagnostic criteria score greater ≥
6, the distribution was 3～13 and the average value was 8.6 ± 2.2. The major abnormal issues were elevated
transaminase (69/70, 98.6%), elevated jaundice (67/70, 95.7%), elevated white blood cells (61/70, 87.1%),
coagulation dysfunction (50/70, 71.4%), renal insufficiency (50/70, 71.4%), ascites or bright liver showed by
ultrasonography (50/70, 71.4%) and renal insufficiency (50/70, 71.4%). The study found that with the score
increased, the incidence of serious complications such as postpartum hemorrhage, liver failure, acute kidney
injury, pulmonary infection and the need for blood purification support were gradually increased except
premature delivery. Conclusion Swansea diagnostic criteria can diagnose AFLP accurately, the score can
reflect the severity of the disease and the intensity of treatment intervention.