Abstract: Objective To investigate the clinical features, diagnosis and treatment methods of acute fatty
liver of pregnancy (AFLP). Methods Clinical data of 39 pregnant women with acute fatty liver of pregnancy
were collected and analyzed retrospectively. All the cases were presented from January 2004 to April 2016 in
Beijing Youan Hospital, Capital Medical University. The incidence of maternal and neonatal complications
were summarized. The patients were divided into two groups according to whether they were complicated
with hepatic or renal failure, and the incidence of complications between the two groups were compared.
Results Out of the 39 cases with AFLP, 37 cases occurred upper gastrointestinal symptoms or jaundice. The
laboratory examination results showed that all patients had elevated AST and ALT, abnormal coagulation
function, elevated cholinesterase and bilirubin (mainly were direct bulirubin). Most of the cases were
accompanied with abnormal renal function and hypoglycemia. In the 39 patients, there were 12 cases with
hepatic encephalopathy, 9 cases with hepatic failure, 23 cases with ascites, 20 cases with abdominal infection,
11 cases with pleural effusion, 16 cases with renal inadequacy, 18 cases with postpartum hemorrhage and 6
cases with gestational hypertension disease. There were 26 cases who delivered in Beijing Youan Hospital,
Capital Medical University, and out of whom 12 cases were premature delivery, 11 cases occurred asphyxia
neonatorum and 3 cases were stillbirth. Conclusions AFLP is a severe complication in pregnancy, which
often occurs in the third trimester of pregnancy and has a high risk for both mothers and fetus. In clinical
procedures, more attention should be paid to the symptoms of the patients in order to make early diagnosis
and treat actively and timely termination can improve the outcomes of mothers and infants.