Abstract: Objective To investigate the clinical characteristics of HBV reactivation in pregnant and lying-in
women with chronic HBV infection during low replication time. Methods A prospective study was conducted
on the HBV reactivation index (HBeAg, HBV DNA and ALT) of pregnant women with chronic hepatitis B
virus (HBV) infection from July 2014 to July 2015 in Beijing Ditan Hospital, Capital Medical University.
Results Total of 520 chronic HBV infection pregnant and lying-in women with HBsAg positive were
selected, and out of whom 170 cases were in low replication time. A complete data analysis was conducted
with 151 cases, among which 40 cases (26.49%) were with HBV reactivation, 8 cases (cumulative activation
rate was 5.30%) were in the first trimester [(12 ± 1) weeks], 8 cases (cumulative activation rate was 10.60%)
were in the second trimester [(24 ± 1) weeks], 10 cases (cumulative activation rate was 17.20%) were in the
third trimester [(36 ± 1) weeks] and 14 cases were in postpartum (cumulative activation rate was 26.50%).
The difference was statistically significant (χ 2 = 29.821, P ＜ 0.001). Conclusions With the passage of time,
the HBV cumulative reactivation rate of pregnant and lying-in women with chronic HBV infection during
low replication time increased significantly. Therefore, the monitoring of HBV-related indicators should be
concerned during the whole perinatal period to ensure the safety of maternal and child.