Abstract: Liver failure is rare in perinatal period and will be a threaten to the safety of pregnant women
and fetus once occurred. There is no standard procedure in the treatment of acute liver failure in pregnancy,
especially in the choice of liver transplantation. With the improvements of various technologies, liver
transplantation has become a final choice for patients with partial liver failure during perinatal period. This
paper reported a case with hepatitis B combined acute-on-chronic liver failure cured by liver transplantation
during perinatal period.