Abstract: Real world clinical studies refer to clinical studies conducted in real practice to evaluate effects of
certain therapy on patients’ health. Real world study (RWS) data may get from multiple sources which include
hospital, community and home. Real world studies can be divided into observational studies and experimental
studies. Real world studies always enrolled large sample size of real practice patients. In evidence based
medicine system, evidence from real world studies are important supplement to evidence from randomized
controlled studies. The concept of real world studies was literally reported in 1993 for the first time. Globally,
real world studies develop rapidly in recent 10 years. Yet quality of real world studies in China still need to be
improved. We drafted this practice algorithm on real world study to provide reference to related clinicians and
researchers.