Abstract: Sustained hepatic inflammation is an important factor in developing and progression of chronic
liver diseases. Chemokines play important roles through regulating the activities, migration, recruitment of
hepatocytes, Kupffer cells, hepatic stellate cells, endothelial cells and circulating immune cells. Monocyte
chemoattractant protein 1 (MCP-1) belongs to CC chemokine family, exerts enormous functions in activities
and migration, recruitment of mononeuclear phagocyte, neutrophil, lymphocyte in inflammatory response
and tissue damage. MCP-1 has effect on developing and progression of chronic hepatisis B, chronic hepatisis
C, nonalcoholic fatty liver disease, hepatic fibrosis and spontaneous bacterial peritonitis in hepatic cirrhosis.
This article reviewed the research progress of related relationship of MCP-1, chronic liver diseases and its
complications in recent years.