Abstract: Objective To observe the effects of Compound Glycyrrhizin on CD4 + CD25 + FoxP3 + regulatory T
cells (Treg) in peripheral blood of patients with type 1 autoimmunity hepatitis. Methods Total of 34 patients
who were diagnosed as type 1 autoimmunity hepatitis and received Compound Glycyrrhizin for injection
for 4 weeks in Beijing Ditan Hospital, Capital Medical University from January 2014 to December 2015
were studied by self-control study. The change of proportions of Treg and Th17 cells and ratio of Th17/
CD25 + Foxp3 + in the peripheral blood of patients before and after treatment were detected by Flow cytometry.
Results The levels of ALT, AST, TBil and GGT decreased after treatment, the differences were statistically
z = -5.30, -5.19, -3.43, -4.13; P ＜ 0.001). Proportions of Treg had no statistical difference before
and after treatment (t = 0.81, 0.48, -0.39, -0.84; P ＞ 0.05). Proportions of Th17 cells and ratio of Th17/
CD25 + Foxp3 + t = 2.56, 2.34; P = 0.02, 0.04). Conclusions Compound
Glycyrrhizin cab affect the ratio of Th17/CD25 + Foxp3 + proportions. It may relieve the liver function of
patients with AIH by restoring the balance of Th17/CD25 + Foxp3 + proportions.