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2型糖尿病男性患者血清睾酮水平低下对非酒精性脂肪性肝病的影响

作者：吴桂林庞力超黎文英

单位：湛江市第一中医医院内分泌科广东湛江 524043

关键词：糖尿病 2型血清睾酮脂肪肝非酒精性

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出版年,卷(期):页码：2017,9(4):90-93

摘要：

摘要：目的研究2型糖尿病（type 2 diabetes mellitus，T2DM）男性患者血清睾酮水平低下对非酒精
性脂肪性肝病（non-alcoholic fatty live disease，NAFLD）的影响。方法采用随机数字表法抽取160例
广东省湛江市第一中医医院收治的T2DM男性患者进行临床分析，根据是否合并NAFLD分为NAFLD
组（75例）非NAFLD组（85例），同时按照超声检查结果将NAFLD组分为中重度组（40例）和轻
度组（35例）2个亚组，分析NAFLD与睾酮水平（testosterone，TT）间的关系。结果 NAFLD组患者
血清ALT、GGT和TG水平均高于非NAFLD组，HDL-C和TT水平均低于非NAFLD组，差异有统计学
意义（P均＜ 0.05）；两组患者的ALP和AST差异无统计学意义（P ＞ 0.05）。轻度NAFLD患者的
TT值为（3.76 ± 1.56）ng/ml，中重度NAFLD患者的TT值为（3.01 ± 0.97）ng /ml，差异有统计学意
义（t = 3.697，P ＜ 0.001）。TT水平与血清ALT、GGT、TG呈负相关（r值分别为-0.619、0.782、
0.503，P值分别为0.001、＜0.001、0.003），与HDL-C呈正相关（r = 0.592，P = 0.002）。结论对
于男性T2DM患者，血清总睾酮水平降低与其发生NAFLD具有相关性，对血清总睾酮水平进行监测
可为血清睾酮水平低下2型糖尿病男性患者NAFLD的预防及治疗提供参考。

Abstract: Objective To investigate the effects of low levels of serum testosterone on non-alcoholic fatty
liver disease (NAFLD) in male patients with type II diabetes mellitus (T2DM). Methods Total of 160 male
patients with T2DM in Zhanjiang First Hospital of Traditional Chinese Medicine were selected by random
number table and were divided into NAFLD group (75 cases) and non NAFLD group (85 cases) depending
on whether complicated with NAFLD. The NAFLD group was divided into 2 subgroups according to the
results of ultrasonography: moderate severe group (40 cases) and mild group (35 cases). The relationship
between NAFLD and testosterone (TT) levels was observed. Results The serum levels of ALT, GGT and TG
of patients in NAFLD group were higher than those in non NAFLD group, and the levels of HDL-C and TT
P ＜ 0.05). There
P ＞ 0.05). The TT value of
patients with mild NAFLD was (3.76 ± 1.56) ng/ml while the value of TT in patients with moderate severe
t = 3.697, P ＜ 0.001). The level
of TT was negatively correlated with serum levels of ALT, GGT and TG (r = -0.619, 0.782, 0.503; P = 0.001, ＜
0.001, 0.003), and was positively correlated with HDL-C (r = 0.592, P = 0.002). Conclusion For male patients
with T2DM, the decrease of serum levels of total testosterone is related to the occurrence of NAFLD, and
monitoring it can provide a reference for prevention and treatment.

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