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苦参素胶囊对慢性乙型肝炎患者HBeAg和HBV DNA阴转率作用的Meta分析

作者：郑洋 1 赵铁建 2

单位：1.广西中医药大学基础医学院南宁 530000 2.广西中医药大学基础医学院生理教研室南宁 530000

关键词：苦参素胶囊 HBeAg阴转率 HBV DNA阴转率 Meta分析

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出版年,卷(期):页码：2018,10(1):18-22

摘要：

摘要：目的分析苦参素胶囊对慢性乙型肝炎（chronic hepatitis B，CHB）患者HBeAg和HBV DNA阴
转率的影响。方法以苦参素胶囊、氧化苦参碱、慢性乙型肝炎和marine capsules为检索词，检索自建
库到2017年8月中国知网、万方数据、重庆维普、PubMed和Embase数据库中苦参素胶囊治疗CHB的
随机对照试验。采用Jadad量表对文献质量进行评估，采用RevMan 5.3软件进行Meta分析。结果共纳
入13篇文献，总计1523例患者，治疗组1048例，对照组475例，经过Meta分析得出，苦参素胶囊可提
高CHB患者HBeAg和HBV DNA的阴转率，减少病毒复制，差异有统计学意义（P ＜ 0.05）。结论苦
参素胶囊可显著提高CHB患者HBeAg和HBV DNA的阴转率且不良反应轻微。

Abstract: Objective To analyze the effect of the marine capsule on the negative conversion rates of HBeAg
and HBV DNA in patients with chronic hepatitis B (CHB). Methods Randomized and controlled trials on the
treatment of CHB with matrine capsule in CNKI, Wanfang Data, Chongqing Weipu, PubMed and Embase
database from database construction to August 2017 were retrieved with the key words matrine capsule,
oxymatrine, chronic hepatitis, marine capsules, etc. The literature were evaluated by Jadad scale, and Meta
analysis was operated by RevMan5.3. Results A total of 13 studies and 1523 patients (1048 patients in
treatment group and 475 patients in control group) were included. Marine capsules could greatly improve
the negative conversion rates of HBeAg and HBV DNA and could reduce virus replication according to the
results of Meta analysis (P ＜ 0.05). Conclusion Marine capsules can significantly increase the negative
conversion rates of HBeAg and HBV DNA in patients with CHB, with little adverse effects.

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