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丙型肝炎患者血清HCV载量与肾功能损伤程度的关系

作者：李海东 1 李连友 1 孙丽红 2 尚明全 1 柏立欣 1

单位：1.赤峰市医院检验科内蒙古自治区赤峰 024000 2.赤峰学院附属医院检验科内蒙古自治区赤峰 024005

关键词：肝炎病毒丙型尿素氮胱抑素C

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出版年,卷(期):页码：2018,10(1):35-39

摘要：

摘要：目的探讨丙型肝炎患者血清HCV载量与肾功能损伤程度的关系。方法随机选取2016年6月至
2016年12月于赤峰市医院就诊的203例HCV感染者及57例健康对照为研究对象，分别检测血清HCV
RNA载量、BUN、Cr、UA及CysC水平，分析HCV载量与肾功能损伤的相关性。结果 HCV感染组患
者血清BUN及CysC水平均显著高于健康对照组，差异有统计学意义（t值分别为4.022、6.555，P均＜
0.001），血清Cr及UA差异无统计学意义（t值分别为1.535、0.071，P值分别为0.546、0.837）。HCV
感染者的病毒载量与血清CysC呈显著负相关（r = -0.232，P = 0.009）。结论 CysC可能与控制HCV的
复制有关，联合检测血清BUN、Cr及CysC水平可更好地评估HCV感染者的肾功能损伤。

Abstract: Objective To investigate the correlation between kidney injury and viral load in patients with
hepatitis C. Methods Total of 203 patients with HCV infection and 57 healthy controls in Chifeng Hospital
from June 2016 to December 2016 were randomly selected. The levels of serum urea nitrogen, creatinine
(Cr), uric acid (UA), cystatin C (CysC) and HCV RNA load were detected. Results The levels of serum
urea nitrogen and cystatin C in patients with HCV infection were higher than those of healthy controls, the
differences were statistically significant (t = 4.022, 6.555; P ＜ 0.001). There was no significant difference
between serum Cr and UA (t = 1.535, 0.071; P = 0.546, 0.837). There was a significant negative correlation
between CysC levels and HCV RNA load in patients with HCV infection (r = -0.232, P = 0.009). Conclusions
CysC may be associated with HCV replication, combined detection of BUN, Cr and CysC can better evaluate
renal function injury in patients with HCV infection.

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