中国肝脏病杂志(电子版)

位置：首页 >> 期刊文章

西医综合疗法联合益气疏肝、醒脾化湿通络法治疗乙型肝炎相关肝衰竭

作者：曾义岚胡蓉王丽王林李继科陈竹张鸿毛创杰段萌

关键词：肝功能衰竭肝炎病毒乙型中西医结合疗效

分类号：

出版年,卷(期):页码：2018,10(1):45-49

摘要：

摘要：目的观察西医综合疗法联合益气疏肝、醒脾化湿通络法治疗乙型肝炎相关肝衰竭（HBV-related
liver failure，HBV-LF）的临床疗效。方法将232例乙型肝炎相关肝衰竭患者随机分入西医组（119例）
和中西医结合组（113例），西医组患者采用西医综合治疗，中西医结合组患者在西医治疗的基础上口
服中药汤剂肝脾疏络饮，比较两组的疗效、并发症发生率、病死率、人工肝次数及中医证候积分。结果
治疗2周时，中西医结合组患者血清TBil和DBil水平显著低于西医组（F值分别为6.477、11.700；P值分别
为0.002、0.001），血清TBil下降程度亦显著高于西医组（F = 11.7，P ＜ 0.001）。治疗24周时，中西医
结合组患者入组后人工肝次数及人工肝费用均显著低于西医组（F = 4.76、9.065，P = 0.03、0.004）。中
西医结合组在治疗1周、2周、3周、4周及8周时的中医证候积分均显著低于西医组（P均＜ 0.05）。结论
西医综合疗法联合益气疏肝、醒脾化湿通络法治疗乙型肝炎相关肝衰竭可改善患者的肝功能，降低病死
率，减少人工肝次数及医疗费用，值得进一步研究和推广。

Abstract: Objective To investigate the curative effect of Yiqi Shugan Xingpi Huashi Tongluo therapy combined
with western medicine in treatment of HBV-related liver failure. Methods Total of 232 cases with HBV-related
liver failure were selected and randomly divided into western medicine group (119 cases) and integrated traditional
Chinese and western medicine group (113 cases). Patients in western medicine group were given western combined
therapy, while patients in integrated traditional Chinese and western medicine group were given Gan-pi-shu-luo
decoction on the basis of western medicine group. Curative effect, mortality rate, complication rate, artificial liver
number and traditional Chinese medicines (TCM) syndrome integral were compared. Results After 2 weeks’
treatment, the serum TBil and DBil levels of patients in integrated traditional Chinese and western medicine group
were significantly lower than those in western medicine group (F = 6.477, 11.700; P = 0.002, 0.001), and the
decrease of serum TBil was also significantly higher than that in western medicine group (F = 11.7，P ＜ 0.001).
After 24 weeks’ treatment, the artificial liver number and cost of patients in integrated traditional Chinese and
western medicine group were significantly lower than those in western medicine group (F = 4.76, 9.065; P = 0.03,
0.004). The TCM syndrome of patients in integral integrated traditional Chinese and western medicine group were
significantly lower than those in western medicine group at week 1, week 2, week 3, week 4 and week 8 (P ＜ 0.05).
Conclusions Yiqi Shugan Xingpi Huashi Tongluo therapy combined with western medicine can effectively improve
liver function, reduce mortality and requency or cost of artificial liver therapy of patients with HBV-related liver
failure, which is worthy of further research and clinical application.

基金项目：

作者简介：

参考文献：

服务与反馈：

【文章下载】【加入收藏】