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血清chemerin水平与非酒精性脂肪性肝病的相关性

作者：吕骥闫丽丽贾红玉吕喆徐梅梅

单位：秦皇岛市第一医院内科河北秦皇岛 066000

关键词：脂肪肝非酒精性 chemerin 胰岛素抵抗

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出版年,卷(期):页码：2018,10(1):54-58

摘要：

摘要：目的研究血清chemerin水平与非酒精性脂肪性肝病（non-alcoholic fatty liver disease，
NAFLD）的相关性。方法选取2015年6月至2016年8月秦皇岛市第一医院收治的NAFLD患者56例
为研究对象，并从该院体检中心随机抽取同期糖耐量试验正常者60例为对照组。检测并比较两组受
试者血清chemerin水平、糖化血红蛋白（hemoglobin A 1C ，HbA 1C ）、胰岛素抵抗指数（homeostasis
model assessment-insulin resistance index，HOMA-IR）、甘油三酯（triglyceride，TG）、高密度脂
蛋白胆固醇（high density lipoprotein cholesterol，HDL-C）、体重指数（body mass index，BMI）及
腰臀比（waist-to-hip ratio，WHR）等指标。采用Pearson相关分析空腹血清chemerin水平与上述各指
标的相关性并采用多元线性回归分析血清chemerin的影响因素。结果 NAFLD患者血清chemerin水平
[（79.71 ± 10.36）nmol/ml]显著高于健康对照者[（62.43 ± 11.92）nmol/ml；t = 8.308，P ＜ 0.001]。
空腹血清chemerin水平与BMI、WHR、HbA 1C 、HOMA-IR和TG呈正相关（r = 0.382、0.492、0.442、
0.590、0.295，P均＜ 0.05），与HDL-C呈负相关（r = -0.314，P = 0.003）。以chemerin为因变量进
行多元线性回归分析显示，HbA 1C 、LgHOMA-IR和WHR为空腹血清chemerin水平的影响因素（P ＜
0.001）。结论 NAFLD患者血清chemerin水平增高，糖化血红蛋白、胰岛素抵抗指数和腰臀比是影响
chemerin的关键指标，提示chemerin与NAFLD的发生发展密切相关。

Abstract: Objective To investigate the correlation between serum chemerin level and non-alcoholic fatty liver
disease (NAFLD). Methods A total of 56 patients with NAFLD and 60 health controls with normal glucose
tolerance in the First Hospital of Qinhuangdao from June 2015 to August 2016 were selected. The levels of
serum chemerin, hemoglobin A 1C (HbA 1C ), homeostasis model assessment-insulin resistance index (HOMA-
IR), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), body mass index (BMI) and waist-to-hip
ratio (WHR) were tested and compared. Pearson anlysis was used to analyze the correlation between serum
chemerin and the above indexes and multiple linear regression was employed to explore the influence factors
of serum chemerin level. Results The serum chemerin levels of patients in NAFLD group were significantly
higher than those of the control group [(79.71 ± 10.36) nmol/ml vs (62.43 ± 11.92) nmol/ml; t = 8.308, P ＜
0.001]. The levels of serum chemerin were positively correlated with BMI, WHR, HbA 1C , LgHOMA-IR and
TG (r = 0.382, 0.517, 0.442, 0.590, 0.295; P ＜ 0.05), and were negatively correlated with HDL-C (r = -0.314,
P = 0.003). Multiple linear regression analysis showed that HbA 1C , LnHOMA-IR and WHR were the influence
factors of serum chemerin level (P ＜ 0.001). Conclusions Patients with NAFLD have higher level of serum
chemerin, HOMA-IR, HbA 1C and WHR are key indicators of serum chemerin, suggesting that chemerin may
be closely associated with non-alcoholic fatty liver disease.

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