Abstract: Objective To investigate the different types and biochemical indexes in patients with drug-
induced liver failure. Methods Total of 102 cases with drug-induced liver failure patients in our hospital
from March 2010 to March 2017 were selected. The information of the patients were recorded, including
gender, age, primary disease, symptoms and signs, drug use and related laboratory indicators. The differences
of biochemical indexes between patients in effective group and unrecovered group were compared. Results
Most drug-induced liver failure were caused by proprietary Chinese medicines (46/102, 45.0%) and anti-TB
drugs (27/102, 26.4%). Among all types of liver failure, the most common was hepatocellular type (64/102,
62.74%) and the second is cholestatic type (28/102, 27.45%). The ALB level of patients in effective group
was significantly higher than that in unrecovered group (t = 0.254, P = 0.001). The serum levels of total bile
acid (TBA), direct bilirubin (DBil) and prothrombin time (PT) of patients in effective group were significantly
lower than those in unrecovered group (t = 0.341, 0.256, 0.413, 0.510; P ＜ 0.001). Conclusion The clinical
types of drug-induced liver failure were various, and the biochemical indexes of patients in effective group
were different from those in unrecovered group, which is worthy of being paid attention.