Abstract: Objective To investigate the clinical effect of percutaneous microwave ablation and laparoscopic
microwave ablation in treatment of small hepatocellular carcinoma patients with special site. Methods Total
of 60 small hepatocellular carcinoma patients with special site in Gaozhou People’s Hospital from March
2013 to March 2017 were selected and randomly divided into observation group and control group, 30 cases
in each group. Patients in control group were treated with percutaneous microwave ablation, and patients
in observation group were treated with microwave ablation under laparoscope. The new lesions, tumor
focus, ablation, tumor recurrence, operation parameters, liver function and complications were observed and
compared between the two groups. Results One week after the operation, the cure rate of tumor lesions in
observation group was significantly higher than that in control group (χ 2 = 7.39, P = 0.01), and there was no
significant difference in tumor recurrence rate between the two groups (χ 2 = 1.45, P = 0.68). There was no
significant difference in serum TBil, ALT and AST levels between the two groups before and after operation
(P ＞ 0.05). The incidence of complications in observation group was significantly lower than that in control
group (χ 2 = 6.52, P ＜ 0.001). Conclusions The clinical effect of laparoscopic microwave ablation for small
hepatocellular carcinoma patients with special site is better, the ablation rate of tumor focus is higher, and the
incidence of complications is lower, which had a high clinical application value and is worth popularizing.