Abstract: Realization of HBsAg negative conversion and transformation is the ideal endpoint of CHB
therapy. We reported a case of CHB patients with HBeAg positive who was given combination treatment of
lamivudine (LAM) and interferon (IFN) for 48 weeks, and HBsAg conversed to be negative. On the basis of
anti-viral treatment, the patients were inoculated with hepatitis B vaccine (0 month, 1 month and 6 month).
The level of HBsAb was 50 mIU/ml at 64 week and 150 mIU/ml at 72 week. The patients get clinical cure
and discontinued antiretroviral treatment. Among the different possibilities contemplated, combined treatment
is effective in HBV infection. The effectiveness of combined treatment should be researched with hepatitis B
vaccine or mmunopotentiator, as occasion requires.