|
摘要：
|
|
摘要：目的 通过核素首次通过法测定肝动脉血流指数（hepatic artery blood flow index，HBI）预测日本血
吸虫病肝纤维化程度。方法 选取67例日本血吸虫病患者为研究对象，采用METAVIR评分系统评估纤维化
程度。静脉注射二磷酸锝 99 （ 99m Tc-MDP）后，即刻采用首次通过法测定肝血流指数。采用受试者操作特
征曲线下面积（area under receivers operating characteristic curve，AUROC）衡量肝血流指数预测肝纤维化的
价值。结果 肝血流指数与肝纤维化程度呈正相关（r = 0.717，P ＜ 0.001）。肝血流指数预测显著肝纤维
化的AUROC为0.916（95%CI：0.844～0.987，P ＜ 0.001），截止点为32.77时，敏感性为87.5%，特异性
为62.5%，阳性预测值（positive predictive value，PPV）为70.0%，阴性预测值（negative predictive value，
NPV）为83.3%。血流指数预测严重肝硬化的AUROC为0.832（95%CI：0.729～0.935，P ＜ 0.001），截止
点为40.70时，敏感性为96.3%，特异性为58.8%，PPV为70.0%，NPV为96.5%。结论 核素首次通过法测定
肝动脉血流指数是一种新型评估日本血吸虫病肝纤维化程度的方法，有助于判断预后。
|
|
Abstract: Objective To predict the degree of liver fibrosis induced by Schistosoma japonicum according to
hepatic artery blood flow index (HBI) measured by nuclide first pass method. Methods Total of 67 patients
with Schistosomiasis japonicum were selected. The degree of liver fibrosis was assessed by METAVIR
scoring system. HBI was measured by injection of nuclear isotope technetium-99-methylene diphosphate
( 99m Tc-MDP). The area under the receiver’s operating characteristic curve (AUROC) was used to measure the
diagnostic value. Results There was a positive correlation between hepatic blood flow index and the degree
of liver fibrosis (r = 0.717，P ＜ 0.001). The AUROC of hepatic blood flow index in predicting significant
liver fibrosis was 0.916 (95%CI: 0.844～0.987, P ＜ 0.001), the cut-off value was 32.77, the sensitivity was
87.5%, the specificity was 62.5%, the positive predictive value (PPV) was 70.0% and the negative predictive
value (NPV) was 83.3%. The AUROC of hepatic blood flow index in predicting severe liver cirrhosis was 0.832
(95%CI: 0.729～0.935, P ＜ 0.001), the cut-off value was 40.70, the sensitivity was 96.3%, the specificity
was 58.8%, the PPV was 70.0% and the NPV was 96.5%. Conclusion HBI is a novel diagnostic tool for the
assessment of liver fibrosis and is helpful for predicting prognosis.
|
|
基金项目：
|
|
|
|
作者简介：
|
|
|
|
参考文献：
|
|
|
|
服务与反馈：
|
|
【文章下载】【加入收藏】
|
|
|
|