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摘要：
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摘要：随着直接抗病毒药物的不断更新与广泛应用，慢性丙型肝炎的治愈率显著提高。丙型肝炎病毒
耐药相关变异直接影响抗病毒疗效和获得病毒学治愈的机会，已越来越受到关注。本文就丙型肝炎病
毒耐药相关变异对直接抗病毒药物疗效的影响进行综述，以便更好地治疗丙型肝炎。
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Abstact: Along with the continuous renewal and wide use of direct-acting antiviral agents, the cure rate of
chronic hepatitis C improved obviously. However, the resistance associated variants as well as their rapid
emergence during incomplete drug-pressure greatly affect treatment outcome and the chances of virological
cure. In this paper, the effects of drug resistance of hepatitis C virus on the efficacy of direct-acting antiviral
agents were reviewed to facilitate better treatment on hepatitis C.
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