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摘要：
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摘要：目的 探讨肝功能衰竭合并肝硬化患者血清γ-谷氨酰转肽酶（γ-glutamyl transferase，γ-GGT）与前
白蛋白水平的相关性。方法 选取2014年10月至2017年12月在惠州市第一人民医院和南方医科大学南方
医院感染科住院治疗的肝功能衰竭合并肝硬化患者95例为肝功能衰竭组，HBV相关肝硬化患者30例为
肝硬化组，同时选取两院健康人群30例为对照组。检测所有研究对象外周血γ-GGT水平，比较肝功能衰
竭合并肝硬化患者病死组和存活组入院前及入院1周时γ-GGT的变化以及γ-GGT上升者和下降者存活率
的差异。分析肝功能衰竭组患者γ-GGT与前白蛋白和终末期肝病模型（model for end-stage liver disease，
MELD）评分的相关性。结果 入院时肝功能衰竭组、肝硬化组和对照组患者外周血γ-GGT水平分别为
（149.61 ± 69.86）U/L、（123.96 ± 59.52）U/L和（48.28 ± 10.25）U/L，差异有统计学意义（F = 3.619，
P = 0.021）。肝功能衰竭组存活者入院1周时γ-GGT水平显著高于病死者（t = 5.400，P = 0.021）；肝功
能衰竭组中γ-GGT上升者的存活率为71.83%（51/71），显著高于γ-GGT下降者的25.00%（6/24），差
异有统计学意义（t = 5.982，P = 0.001）。肝功能衰竭组患者γ-GGT上升值与MELD评分呈负相关（r =
-0.627，P = 0.001），与前白蛋白呈正相关（r = 0.709，P = 0.021）。结论 γ-GGT不断升高是肝功能衰竭
合并肝硬化患者良好预后的指标之一；前白蛋白与肝功能衰竭合并肝硬化患者血清γ-GGT呈正相关，可
反映机体肝细胞的再生功能。
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Abstract: Objective To investigate the correlation between serum γ-glutamyl transpeptidase (γ-GGT) and
prealbumin in liver failure patients complicated with cirrhosis. Methods Total of 95 liver failure patients
complicated with cirrhosis (liver failure group), 30 patients with HBV-related liver cirrhosis (liver cirrhosis
patients) and 30 healthy controls in Huizhou First People’s Hospital and Nanfang Hospital from October 2014 to
December 2017 were selected. The peripheral blood levels of γ-GGT were detected. The difference of γ -GGT
before admission and 1 week after admission of survival and death patients in liver failure group was compared.
The survival rate of patients with increased and decreased γ -GGT in liver failure group was also compared. The
relationship among γ-GGT, prealbumin and model for end-stage liver disease (MELD) score of patients in liver
failure group was analyzed. Results The peripheral blood γ-GGT levels of patients in liver failure group, liver
cirrhosis group and control group were (149.61 ± 69.86) U/L, (123.96 ± 59.52) U/L and (48.28 ± 10.25) U/L on
admission, respectively. The difference was statistically significant (F = 3.619, P = 0.021). The γ -GGT level
of survival patients was significantly higher than that of dead patients in liver failure group at one week after
admission (t = 5.400, P = 0.021). The survival rate of patients with increased γ-GGT level in liver failure
group was 71.83% (51/71), which was significantly higher than that of patients with decreased γ-GGT level
[25.00% (6/24); t = 5.982, P = 0.001]. MELD score was negatively correlated with the increase of γ-GGT (r =
-0.627, P = 0.001) and the level of prealbumin was positively correlated with the increase of γ-GGT (r = 0.709,
P = 0.021). Conclusions The continuous increase of γ-GGT is one of the indicators of good prognosis in liver
failure patients complicated with cirrhosis. Prealbumin is positively correlated with serum γ-GGT and can
respond to hepatocyte regeneration.
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